Edinson Cavani looks set for a three-week spell on the sidelines after sustaining a thigh injury in PSG's 2-0 home league win over Bordeaux on Friday.
The 26-year-old striker left the field 75 minutes into the victory at the Parc de Princes as PSG extended their lead over Monaco to five points in Ligue 1.
Cavani underwent examination on Saturday, revealed a club spokesman, before confirming the striker would be out of action for at least three weeks.
That means Cavani will miss the first leg of PSG's Champions League tie against Sami Hyypia's Bayer Leverkusen in Germany later this month.
He will also miss PSG's League Cup semi-final tie at Nantes on Tuesday, and next weekend's Ligue 1 clash against fellow big-spending rivals Monaco.
The Uruguay international has flourished alongside Zlatan Ibrahimovic for PSG this season, scoring 20 goals in 30 matches for the club in all competitions.
Cavani is PSG's club-record signing after moving to the Ligue 1 leaders for a French record fee of 64million euros this season.