Serbian three-time defending champion Novak Djokovic advanced to the round of 16 of the Australian Open in convincing fashion, defeating Uzbek Denis Istomin 6-3, 6-3, 7-5 on Friday.

The world No. 2, who has not lost a match since his defeat to top-ranked Rafael Nadal in last year's U.S. Open final, took a two-set lead in just over an hour on the strength of strong serving and efficient use of his break points.

Through sets one and two, Djokovic won 36 of his 46 serve points and coverted all three of his break-point opportunities.

The Serbian lost his serve once in the third set, but he managed to snag two breaks of serve to avoid the tiebreaker and wrap up the match in just under two hours.

Next up for Djokovic in the round of 16 will be Italy's Fabio Fognini, a 7-5, 6-4, 6-4 winner Friday over American Sam Querrey.

In other results Friday involving top men's players, third-seeded Spaniard David Ferrer moved through with a 6-2, 7-6 (7-5), 6-2 win over Frenchman Jeremy Chardy, and seventh-seeded Czech Tomas Berdych cruised to a 6-4, 6-2, 6-2 victory over Bosnia and Herzogovina's Damir Dzumhur.

Germany's Florian Mayer recorded the day's biggest upset, knocking off big-serving Pole Jerzy Janowicz, the No. 20 seed, 7-5, 6-2, 6-2.

In women's action, American world No. 1 Serena Williams defeated Slovak Daniela Hantuchova 6-3, 6-3 for her 61st match win at the Australian Open, a tournament record. EFE