Arsenal have been drawn to host Tottenham in the FA Cup third round, while Manchester United will face Swansea and Liverpool have a home tie.
Arsenal's most recent piece of silverware came in the 2005 FA Cup but if they are to repeat that success this season they will have to overcome Spurs at the first hurdle after the two sides were paired together in the pick of Sunday's draw.
The pair are among the most successful clubs in the competition's history, with Arsenal having lifted the trophy on 10 occasions while Spurs have won it eight times.
The only side to have won the FA Cup more times are Manchester United, who will also be involved in an all-Premier League tie in the third round after being paired at home to Swansea.
United might have been hoping for a more favorable cup draw following a hugely disappointing start to the defense of their league title which has seen them lose five times in 15 matches under new boss David Moyes, with their latest setback Saturday's 1-0 loss to Newcastle at Old Trafford.
United have won the FA Cup 11 times, but the last time was back in 2004.
FA Cup holders Wigan start off against MK Dons while the side they beat in May's final, Manchester City, face a short trip to Blackburn.