Atletico Madrid routed Austria Wien 4-0 Wednesday to put a lock on first place in Champions League Group G and assure itself a berth in the round of 16, while FC Barcelona will also advance thanks to a 3-1 win over AC Milan.
Defending champion Bayern Munich and Manchester City clinched on Tuesday.
Real Madrid, Paris Saint-Germain, Chelsea and Arsenal all look likely to move on to the next phase of the tournament.
Zenit St. Petersburg and Porto tied 1-1 in Wednesday's other Group G match, leaving the Russian side at 5 points, 1 ahead of the Portuguese side and 7 behind Atletico, which has won all four of its matches.
Powered by two goals from Lionel Messi, Barça opened up a 5-point lead over AC Milan in Group H, where Ajax topped Celtic 1-0 on Wednesday to improve to 4 points, one better than the Scottish team.
The Group F race grew tighter Wednesday with Arsenal's 1-0 away victory over Borussia Dortmund and Napoli's 3-2 win against also-ran Olympique Marseille.
Napoli and the Gunners are now tied at 9 points, while Dortmund has 6.
In Group E, Chelsea dominated Schalke 04, winning 3-0 to claim first place with 9 points, 3 ahead of the German club and 4 points better than Basel, which played to a 1-1 draw with Steaua Bucarest.