Designated hitter David Ortiz and first baseman Mike Napoli drove in three runs apiece and Jon Lester dominated on the mound to lead the Boston Red Sox to an 8-1 home victory over the St. Louis Cardinals in Game 1 of the World Series.

The Red Sox got all the runs they would need in the bottom of the first inning of Wednesday night's game when Napoli connected on a double to left center off of starter Adam Wainwright that scored three base runners.

An inning later, second baseman Dustin Pedroia made the score 4-0 with a run scoring single and then Ortiz brought another run home with a bases-loaded sacrifice fly to deep right field.

The play proved costly to the Cardinals in more ways than one, as right fielder Carlos Beltran made a stellar catch to rob Ortiz of a grand slam but injured his ribs when he crashed into the wall.

The 36-year-old Beltran, known as one of baseball's top postseason hitters, finished the inning but was then taken out of the game and taken to a local Boston hospital for tests.

The score remained 5-0 until the bottom of the seventh inning, when Ortiz smashed a home run over the right field wall in Fenway Park that scored Pedroia.

Boston tacked on one last run in the eighth on a sacrifice fly off the bat of third baseman Xander Bogaerts, while the Cardinals' lone run came in the top of the ninth on a solo home run by left fielder Matt Holliday.

Although the Cardinals supposedly had the slight edge in the pitching match-up, Lester turned in the much better outing on Wednesday night, giving up just five hits and no runs in 7 2/3 innings.

Wainwright, meanwhile, surrendered five runs - though sloppy defense meant only three of them were earned - and exited after just five innings of work.

Game 2 will be played Thursday night in Boston before the series shifts to St. Louis. EFE