Pachuca lost their 100 per cent record in Mexico's Apertura as they slipped to a 1-0 defeat against Tijuana.
Diego Olsina's goal three minutes into the second half ended the visitors' two-match winning streak at the start of the campaign and moved Tijuana up to fourth.
Cruz Azul missed out on the chance to join Leon and Pachuca on six points as they were held to a 1-1 home draw by Chiapas.
Avilies Hurtado gave Chiapas the lead with 20 minutes remaining but Mariano Pavone levelled two minutes later and that was the end of the scoring.
At the other end of the table, Atlante and Atlas are still seeking their first three-point return after a 1-1 draw.
Atlas led through Omar Bravo's goal on the half hour - but Angel Sepulveda earned Atlante their first point of the season, which moves them off the foot of the table.