Bolton Wanderers midfielder Stuart Holden's run of bad luck continues after he sprained his right knee early in the United States' 1-0 win over Panama in the CONCACAF Gold Cup final.

U.S. coach Jurgen Klinsmann said after the match Sunday that Holden's latest injury appears to be ''very serious.''

Holden, who was sidelined for more than two years after previous injuries to his right knee, took a knock on his left knee about 20 minutes into the first half, but grabbed his right knee after he hit the ground.

Trainers worked with him on and off the field. As Holden sat on the bench, his head buried in his hands, teammates patted him on the head and shoulders trying to console him.

He walked to the locker room a short time later, and was limping visibly when he rejoined his teammates for the victory ceremony.

''We are very, very concerned about Stuey's situation,'' Klinsmann said. ''I'm not a doctor ... but Stuart's a player that when something happens, he knows. It's not looking good right now.''

Holden initially injured his right knee against Manchester United on March 19, 2011. He returned from surgery to play in a League Cup match that September, then had a second surgery on his left knee eight days later. He did not return to Bolton until this Jan. 15, and did not rejoin the Americans until their May camp.

''We are very, very sad for him,'' Klinsmann said. ''It's not looking very good.''