Barcelona president Sandro Rosell confirmed on Friday that manager Tito Vilanova will leave the club due to health reasons.
Vilanova only took over from Pep Guardiola last summer but his tenure has been overshadowed by health concerns. The former Barclelona B boss missed a chunk of the season after undergoing treatment in the United States for a cancer relapse.
He had orginally been diagnosed with parotid gland cancer in November 2011. Vilanova is understood to have suffered a further setback, with the challenge of leading one of Europe's powerhouses deemed too detrimental to his condition.
Vilanova had been scheduled to have the "pioneering treatment" this summer but it has been brought forward, with Barca having won the Primera Division title with three games to spare this past season.
The 44-year-old spent two months in New York earlier this year undergoing radiotherapy and chemotherapy treatment for cancer, having twice had surgery on his parotid gland in Spain over the last 18 months.