American Serena Williams became the latest big-name casualty at this year's Wimbledon, falling in the fourth round to dangerous German Sabine Lisicki 6-2, 1-6, 6-4 on Monday.
The five-time champion and top seed had not lost a set in three routine wins over Luxembourg's Mandy Minella, Frenchwoman Caroline Garcia and Japan's Kimiko Date-Krumm, but found herself in trouble on Centre Court against an opponent that was able to match her in the power department.
Williams seemed to seize control of the round of 16 match when she stormed back from an early deficit to take the second set easily and go up a service break in the third set.
But Lisicki showed impressive poise and resilience to battle back and then take a 5-4 lead when the world No. 1 missed an overhead smash on break point.
The 24th-ranked German then finished off the contest in the next game with a forehand winner on match point.
Next up for Lisicki in Tuesday's quarterfinals will be Estonia's Kaia Kanepi, who disappointed the home crowd by edging Britain's Laura Robson 7-6 (8-6), 7-5.
Serena, who brought a 34-match winning streak into Monday's match, is the latest former champion of this event to be upset by a far less accomplished player.
In the first week, seven-time champion Roger Federer, two-time champ Rafael Nadal and Maria Sharapova, who won this prestigious grass-court event in 2004, all lost to players ranked outside the top 100.
In other round of 16 results Monday, Lukas Kubot and Jerzy Janowicz set up an unprecedented all-Polish quarterfinal at a Grand Slam tournament with five set wins.
Kubot narrowly defeated France's Adrian Mannarino 4-6, 6-3, 3-6, 6-3, 6-4 thanks to 26 aces, while his big-serving countryman overcame Austria's Jurgen Melzer 3-6, 7-6 (7-1), 6-4, 4-6, 6-4.
Those results also guarantee that the Eastern European country will have its first-ever Grand Slam men's semifinalist.
Spain's David Ferrer, meanwhile, advanced to his second straight Wimbledon quarterfinal with a 6-7 (3-7), 7-6 (8-6), 6-1, 6-1 victory over Croatia's Ivan Dodig.
In other women's singles round of 16 results, eighth-seeded Czech Petra Kvitova, the 2011 champion, defeated Spain's Carla Suarez-Navarro 7-6 (7-5), 6-3, China's Na Li, the No. 6 seed, routed Italy's Roberta Vinci 6-2, 6-0, 20th-seeded Belgian Kirsten Flipkens defeated Italy's Flavia Pennetta 7-6 (7-2), 6-3, and 17th-seed American Sloane Stephens rallied to defeat Puerto Rico's Monica Puig 4-6, 7-5, 6-1 EFE