Top seeds Novak Djokovic, Andy Murray and David Ferrer all won on Monday to advance to the men's quarterfinals of Wimbledon 2013.
The women's side, however, witnessed the latest in a series of upsets at this year's tournament, as American Serena Williams fell in the fourth round to Germany's Sabine Lisicki 6-2, 1-6, 6-4.
Next up for Lisicki in Tuesday's quarterfinals will be Estonia's Kaia Kanepi, who disappointed the home crowd by edging Britain's Laura Robson 7-6 (6), 7-5.
Serena, who brought a 34-match winning streak into Monday's match, is the latest former Wimbledon champion to be bested by a far less accomplished player.
In the first week, seven-time champion Roger Federer, two-time champ Rafael Nadal and Maria Sharapova, who won the prestigious grass-court event in 2004, all lost to players ranked outside the top 100.
World No. 1 Djokovic of Serbia triumphed over German Tommy Haas 6-1, 6-4, 7-6(4) in a match that lasted two hours and 12 minutes, and moves on to face Czech Tomas Berdych, who beat Austria's Bernard Tomic 6-7(4), 7-6(5), 6-4, 6-4.
Scotland's Murray took two hours and 37 minutes to overcome Russian Mikhail Youzhny 6-4, 7-6(5), 6-1, keeping alive local fans' hope to see a Briton win the Wimbledon men's singles title for the first time since 1936.
Murray's quarterfinal opponent will be Spaniard Fernando Verdasco, who beat Kenny De Schepper of France 6-4, 6-4, 6-4 on Monday.
Verdasco's countryman, David Ferrer, advanced to his second straight Wimbledon quarterfinal with a 6-7 (3), 7-6 (6), 6-1, 6-1 victory over Croatia's Ivan Dodig.
Ferrer will square off next with Argentine Juan Martin Del Potro, who topped Italy's Andreas Seppi 6-4, 7-6(2), 6-3 on Monday.
In other round of 16 results Monday, Lukasz Kubot and Jerzy Janowicz set up an unprecedented all-Polish quarterfinal at a Grand Slam tournament with five set wins.
Kubot narrowly defeated France's Adrian Mannarino 4-6, 6-3, 3-6, 6-3, 6-4 thanks to 26 aces, while his big-serving countryman overcame Austria's Jurgen Melzer 3-6, 7-6 (7), 6-4, 4-6, 6-4.
Those results also guarantee that Poland will have its first-ever Grand Slam men's semifinalist.
In other women's singles round of 16 results, eighth-seeded Czech Petra Kvitova, the 2011 champion, defeated Spain's Carla Suarez-Navarro 7-6 (5), 6-3, China's Na Li, the No. 6 seed, routed Italy's Roberta Vinci 6-2, 6-0, 20th-seeded Belgian Kirsten Flipkens defeated Italy's Flavia Pennetta 7-6 (2), 6-3, and 17th-seed American Sloane Stephens rallied to defeat Puerto Rico's Monica Puig 4-6, 7-5, 6-1. EFE