Manchester United begins the defense of its Premier League title with a tough looking trip to Swansea City, in a game that will mark David Moyes' bow as Sir Alex Ferguson's successor.
New manager David Moyes takes his team to south Wales on August 17, before the returning Jose Mourinho's Chelsea visit Old Trafford the following weekend. A match at Liverpool follows for United on August 31.
Mourinho's men kick off the campaign with a match against newly-promoted Hull at Stamford Bridge, while there are also home games for fellow Champions League hopefuls Manchester City and Arsenal.
Manuel Pellegrini's reign as City boss starts with a home match against Newcastle, who confirmed Joe Kinnear as their director of football on Tuesday. Arsenal are at home to Aston Villa.
The north-London clash is the start of a testing opening to the season for Villa, who have a home match against Liverpool and a trip to Chelsea in the following two games.
Crystal Palace's first game back in the top flight is against Tottenham at Selhurst Park. Cardiff - Championship winners last season - start their campaign at West Ham then have home games against Manchester City and Everton.
Roberto Martinez's first competitive match as Toffees manager is at Norwich, while Merseyside rivals Liverpool start with a home game against Mark Hughes' Stoke.
Elsewhere, Paolo Di Canio's Sunderland start with a home match against Fulham, while West Brom face Southampton at the Hawthorns. Hull's fans will relish their festive program, with Manchester United heading to the KC Stadium on Boxing Day, while Manchester City against Liverpool is another tasty-looking December 26 encounter.
The season wraps up on May 11, with three of the expected title chasers finishing on the road. Chelsea head to Cardiff, Manchester United go to Southampton and Arsenal are at Norwich, with Manchester City at home to West Ham.
Mourinho's first match in his second spell with Chelsea is at home to newly promoted Hull while Manuel Pellegrini's first taste of action as City's new manager comes at home to Newcastle.
''Starting the season at home is a great way for our supporters to show the players they are ready to be behind the team all the way, and at the same time it is a great way for the players to show how much they are motivated and committed,'' Mourinho said.
''I am so happy to start at the Bridge.''
2013-14 Barclays Premier League opening day fixtures:
Arsenal v Aston Villa
Chelsea v Hull
Crystal Palace v Tottenham
Liverpool v Stoke
Man City v Newcastle
Norwich v Everton
Sunderland v Fulham
Swansea v Man Utd
West Brom v Southampton
West Ham v Cardiff
The Associated Press contributed to this report.