Juventus topped Shakhtar Donetsk 1-0 on Wednesday to assure itself of a spot in the Champions League knockout stage, and in the process made Chelsea the first-ever defending champion to be eliminated in group play.
The London club went into the last match of the group phase needing a win against humble Nordsjaelland and a Shakhtar victory over the Italian side to advance to the round of 16.
While the Blues easily routed the Danish team 6-1, Shakhtar - who started the day in first place in Group E - fell short against Juventus and was forced to settle for the second knockout berth.
Already assured of finishing first in Group G, Barcelona battled to a scoreless tie with Benfica and fans at Camp Nou watched with concern as star striker Leo Messi was carried off the pitch on a stretcher after a collision with Benfica's goalkeeper.
Celtic edged Spartak Moscow 2-1 on Wednesday to take second place in Group G.
In Group F, Bayern Munich dominated BATE Borisov 4-1 and Valencia topped Lille 1-0, a result that left the German and Spanish clubs tied at 13 points.
Bayern took first place based on goal differential.
CFR Cluj stunned Manchester United 1-0 on Wednesday, handing the English powerhouse their first home loss in Champions League play since 2009.
United had already clinched first place in Group H, but the Romanian club's hopes of grabbing the second spot were dashed by Galatasaray's 2-1 triumph over Braga.
Though Cluj and Galatasaray each finished with 10 points, the Turkish side prevailed in head-to-head play. EFE