Toluca eased to a 3-1 win at Atlas to hold on to their place at the top of the Apertura table.
Goals from Antonio Naelson (19) and Luis Tejada (24) put the visitors two up at the break.
Hector Mancilla pulled one back seven minutes from the end but Wilson Mathias netted in the closing moments to ensure there was no comeback.
Second-placed Tijuana also won to stay level on points with the leaders, Alfredo Moreno scoring the only goal in a 1-0 win at Queretaro after 38 minutes.
Tijuana had Pablo Aguilar sent off after 56 minutes but the hosts, still without a win this season, could not take advantage.
Raul Jimenez scored after 74 minutes to salvage a 1-1 draw for Club America at home to Morelia.
Carlos Morales had opened the scoring just seven minutes earlier for Morelia, who had Rodrigo Salinas sent off a minute from the end.
Elsewhere, a Mauro Cejas penalty on the hour mark gave Pachuca a 1-0 win over Guadalajara, while Tigres Monterrey and San Luis played out a goalless draw.