San Antonio Spurs guard Manu Ginobili, of Argentina, (20) shoots a 3-point shot over Los Angeles Clippers guard Chauncey Billups during the first half of an NBA basketball game in San Antonio, Wednesday, Dec. 28, 2011. Ginobili scored 24 points as the Spurs won 115-90. (AP Photo/Bahram Mark Sobhani)
San Antonio Spurs center Tim Duncan, left, and Manu Ginobili, right, sit on the bench during the fourth quarter of an NBA basketball game, Thursday, Dec. 29, 2011, in Houston. The Rockets won 105-85. (AP Photo/David J. Phillip)
Ginobili broke the fifth metacarpal in his left hand Monday night during the first half of San Antonio's game against the Minnesota Timberwolves.
The surgery is set for Thursday morning.
"They'll put it out later in more detail, but he's going in in the morning," Spurs coach Gregg Popovich told the Express-News. "They are going to do what they do."
Ginobili went to social media to confirm the procedure to his fans.
"Tmrw I'll have a plate & screws on my beloved left hand. Not thrilled. I'll keep you posted. Thank u all!" Ginobili posted on his Twitter account.
The Spurs activated guard Gary Neal to help replace Ginobili, who was averaging a team-high 17.4 points per game on 59.2 percent shooting.
Losing Ginobili again is a major blow for the Spurs after the two-time All-Star hobbled into the playoffs last year with a sprained elbow. That injury helped doom San Antonio in its first-round loss to Memphis despite a 61-win season.
The 34-year-old Ginobili has become the emotional and offensive centerpiece for the Spurs as Tim Duncan has gotten older. The Spurs host Golden State on Wednesday night.
Contains some reporting by the Associated Press.