MILAN – Juventus remains unbeaten and is now level on points with Milan heading into the winter break. Udinese, which lost its perfect record at the Stadio Friuli, is two points further back.
The match got off to a fast pace and Udinese almost had a clear sight on goal in the seventh minute as a cross was put into the area towards Isla in a dangerous position. But Giorgio Chiellini cleared the threat just in time with a spectacular overhead kick.
Juventus counterattacked and Marcelo Estigarribia found Marchisio on the edge of the area but his effort flew millimeters wide of the right post.
The visitors had the first shot on target in the 10th minute but Simone Pepe fired straight at Udinese goalkeeper Samir Handanovic.
Chiellini then made a rare mistake with a header back toward goal which was well short, allowing Isla to race onto the ball, but onrushing Italy goalkeeper Gianluigi Buffon parried his shot.
Marchisio could have given Juventus the lead 10 minutes from halftime with a fierce curling shot which flew just wide of the right post.
Chiellini came close to scoring six minutes into the second half as he managed to get a header on target in a goalmouth scramble, but Handanovic has conceded just two goals at home all season and was again on hand to save right on the goalline.
Udinese could have broken the deadlock shortly before the hour mark as Antonio Di Natale found Danilo, whose header was tipped over the bar by Buffon.
uaglierella had two chances to secure the points for Juventus as first a shot from distance went just wide of the left post, before he fired another effort straight at Handanovic.
Di Natale had a chance in the final seconds when he opted to shoot on goal from a difficult position instead of passing, and his effort flew wide of the left hand post.
The midweek matches were originally slated to open the Serie A season in late August, but were postponed due to a players' strike.
While the strike was eventually settled, the Italian game continues to be rocked by an ongoing investigation into match-fixing and illegal betting on games.
On Monday, former Atalanta captain Cristiano Doni and 16 other people were arrested across Italy as part of an inquiry focused on several Serie A and B matches from the past two seasons.