Manchester United midfielder Tom Cleverley has been handed his first England call-up following the withdrawals of Jack Wilshere and Michael Carrick from the squad to face Holland at Wembley on Wednesday.
Arsenal manager Arsene Wenger had already claimed that Wilshere would not play due to an ankle injury that prevented the 19-year-old from playing any part in the Gunners' friendly defeat to Benfica on Saturday evening.
That belief was confirmed this lunchtime, with Wilshere heading back to the Gunners for further treatment ahead of the Premier League opener at Newcastle.
Manchester United winger Ashley Young is hoping his move to Old Trafford will keep him in the England team.
Young moved from Aston Villa to United this summer and impressed in Sunday's Community Shield win over Manchester City at Wembley.
Ahead of Wednesday's international friendly against Holland, Young said: "Fingers crossed, it will boost my England chances even more.
"As long as I'm doing well for Manchester United then fingers-crossed I'll be playing for England.''
Young was delighted to win his first trophy as a United player, having set up the first of United's three goals as they came back from 2-0 down.
"It's always a good way to start the season,'' he said.
"We wanted to go out and put in a good performance.''
He added: "When you get Manchester City and Manchester United, it's never friendly but we showed we're the better side.''
Tottenham right-back Kyle Walker admitted he was living his dream by being in the same England squad as players he had looked up to.
"These are the guys I've been watching and it's an honour to be around them.
"I think it's a massive opportunity. Hopefully I can get my start and go from there really.
"It's not really my choice to name the team but I'd like to think I was in contention.''
Walker backed Cleverley, who he played alongside for England Under-21s, to have an impact in the senior squad.
He said: "Tom's a great player. We saw yesterday (in the Community Shield) what he can do on the ball.
"He can deliver a ball, he's very good at crossing and very good at passing.''
Walker welcomed the inclusion of Cleverley and his United team-mate Danny Welbeck - another England Under-21 player - in the squad.
"It's good to have familiar faces around,'' he added.