Timmy Chandler will miss the U.S. game against Mexico next week with a knee injury, and Dallas defender Zach Loyd is taking his spot on the soccer roster.

Chandler was impressive in his U.S. debut in March against Argentina, and Juergen Klinsmann included the German-born defender on the roster for his first game as U.S. coach. But Nuremberg coach Dieter Hecking said Thursday that Chandler had twisted his knee during training, and was questionable for the team's Bundesliga opener against Hertha Berlin on Saturday.

Loyd has played in 21 games this season, scoring once and adding two assists. His only appearance for the U.S. was Jan. 22 against Chile, when he started and played 72 minutes in a 1-1 draw.

The U.S. plays Mexico on Wednesday in Philadelphia.