Paraguayan giants Olimpia took a 2-0 lead in the first leg of its Copa Sudamericana First Round clash with The Strongest.

Goalkeeping errors from Daniel Vaca were behind both goals, which came in the second half of the match.

Former River Plate and Boca Juniors defender Julio Cesar Caceces put the hosts ahead in the 66th minute when Vaca failed to hold Vladimir Marin's free-kick, and the goalkeeper then spilled a header from Pablo Zeballos with 10 minutes left, allowing Adrian Romero to score on the follow-up.

"Victory is the most important thing, but this is a 180-minute match that finishes in La Paz," said coach Gerardo Pelusso.

"We have to consider that we will be playing at high altitude (3,600metres above sea level), but we'll do our best."

However, another Paraguayan side, Nacional, were held to a goalless draw in their match against Bolivia's San Jose, but will hope home advantage can carry them through in the second leg.

In Ecuador, hosts Deportivo Quito claimed a 1-0 win over Venezuela's Deportivo Anzoategui.

Argentinian forward Julio Maximiliano Bevacqua netted the winner in the 62nd minute with a header.