The suspected leader of the Juarez drug cartel was arrested by the Federal Police in the western state of Nayarit, Mexican Attorney General's Office spokesmen told Efe.
Alberto Carrillo Fuentes is now in Mexico City and undergoing questioning.
Carrillo Fuentes, known as "Betty la fea," is at the headquarters of the Siedo organized crime unit of the federal AG's office.
The 47-year-old Carrillo Fuentes faces murder, drug and organized crime charges.
The suspected drug trafficker is the brother of Vicente Carrillo Fuentes, who ran the Juarez cartel for 16 years, and Amado Carrillo Fuentes, who founded the criminal organization.
The Juarez cartel was founded in 1993 by Amado Carrillo Fuentes, who was known as the "Lord of the Skies" for his fleet of aircraft.
Amado's brother, Vicente Carrillo Fuentes, and his son, Vicente Carrillo Leyva, who was arrested in April 2009, took control of the cartel following the drug lord's 1997 death after undergoing plastic surgery to disguise his identity.
The well-educated Carrillo Leyva, known as "the Engineer," was one of the "heirs" to the Juarez cartel, Mexican officials said.
The Juarez cartel, one of Mexico's most violent criminal organizations, has been waging a war against the Sinaloa cartel that has left thousands of people dead in the past few years.
The cartel smuggles drugs and engages in other criminal activities from its base in Ciudad Juarez, located across the Rio Grande from El Paso, Texas.
Alberto Carrillo Fuentes had been working to regain territory lost to rival gangs and in operations staged by Mexican security forces.