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At least 149 people died and 1,403 were wounded Wednesday in clashes across Egypt after security forces forcibly evicted Islamist supporters of ousted president Mohammed Morsi from two sites in Cairo, the Health Ministry said.

The provisional government imposed a month-long state of emergency and a dusk-to-dawn curfew in 12 of Egypt's 27 provinces.

At least 49 people were killed in Cairo and 423 others were wounded, ministry spokesman Mohammed Fathallah told state news agency Mena.

Most of the bloodshed in the capital occurred at the camp located near the Rabia al-Adawiyya Mosque, while at least two people died Wednesday in Islamist protests at Cairo's Mustafa Mahmoud Square against the police operation to dismantle the camps.

The Muslim Brotherhood said "Interior Ministry snipers" had opened fire on the demonstrators in Mustafa Mahmoud.

The protests against the dismantling of the camps spread to other parts of the country, with state television reporting that Muslim Brotherhood supporters attacked the new Library of Alexandria, the modern incarnation of the ancient center of learning.

Amid calls from the international community for restraint, the vice president in the de facto government, Mohammed ElBaradei, submitted his resignation Wednesday in a letter sent to interim head of state Adly Mansour.

"It has become difficult for me to continue bearing responsibility for decisions that I do not agree with and whose consequences I fear," the Nobel Peace Prize laureate wrote.

Morsi's Islamist supporters have held protests in Cairo since his ouster in a July 3 coup, when the armed forces suspended the constitution that he enacted during his abbreviated term in office and named Mansour, the head of the Supreme Constitutional Court, as interim head of state pending fresh elections.

The military acted following days of massive anti-government protests.

Critics accused Morsi and the Brotherhood of doing little to address poverty and Egypt's struggling economy, of failing to advance the goals of the 2011 revolution that forced out strongman Hosni Mubarak and of seeking to monopolize power. EFE