At least 16 people died and 33 others were injured Wednesday in a head-on crash between a bus and a truck in the central Venezuelan state of Guarico, the Interior Ministry reported.

"URGENT: regrettably confirmed 16 dead and 33 injured in the Expresos del Mar bus accident in Calabozo," ministry spokesman Jorge Galindo said on Twitter.

The accident occurred about 4 a.m. in the city of Calabozo, some 260 kilometers (161 miles) by highway south of Caracas, when a bus owned and operated by the Expresos del Mar company collided head-on with a cargo truck carrying bricks.

Both vehicles burst into flame, according to the information supplied by Galindo, who also said that local firefighters were dispatched to the scene to extinguish the blazes.

Highway accidents are frequent occurrences in Venezuela, a country where the roadway infrastructure is generally ill-maintained. EFE