Harold Ramis, who appeared on screen in the hit comedy "Ghostbusters" and directed films such as "Groundhog Day" and "Analyze This," died on Monday, his agent's office told Efe. He was 69.

Ramis passed away at his home in Chicago of complications of autoimmune inflammatory vasculitis, a rare condition he developed several years ago.

At the time of his death he was surrounded by family and friends, according to a communique from his agent's office, UTA.

Ramis made his Hollywood debut as the writer of the 1978 blockbuster "Animal House."

As an actor, his most memorable role was as Dr. Egon Spengler in "Ghostbusters," a comedy starring Bill Murray and Dan Aykroyd that garnered close to $300 million at the box office and spawned a successful sequel.

He was most admired, however, for his work as a director, which began with "Caddyshack" in 1980 and "National Lampoon's Vacation" in 1983, which preceded the screen sensation "Groundhog Day" featuring his great friend Murray.

Later came such titles as "Multiplicity" in 1996 and "Bedazzled" in 2000, though his greatest box-office hit was "Analyze This," the mafioso comedy starring Robert De Niro and Billy Crystal, which also sparked a sequel. EFE